A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone. A characteristic that distinguishes such substances from full receptor agonists and full antagonists is that their action differs in different tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of dissociating undesirable adverse effects from the development of synthetic PR-modulator drug candidates.
"}{"slip": { "id": 50, "advice": "Walking is a perfectly valid solution to traffic congestion problems."}}
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{"type":"standard","title":"Ted Slevin","displaytitle":"Ted Slevin","namespace":{"id":0,"text":""},"wikibase_item":"Q7693732","titles":{"canonical":"Ted_Slevin","normalized":"Ted Slevin","display":"Ted Slevin"},"pageid":23636807,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/5/59/Edward_Slevin_-_Huddersfield.jpeg","width":252,"height":382},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/5/59/Edward_Slevin_-_Huddersfield.jpeg","width":252,"height":382},"lang":"en","dir":"ltr","revision":"1273092860","tid":"32dcfae5-dff8-11ef-adb9-eb6db997d699","timestamp":"2025-01-31T17:24:17Z","description":"Great Britain and England international rugby league footballer","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Ted_Slevin","revisions":"https://en.wikipedia.org/wiki/Ted_Slevin?action=history","edit":"https://en.wikipedia.org/wiki/Ted_Slevin?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Ted_Slevin"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Ted_Slevin","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Ted_Slevin","edit":"https://en.m.wikipedia.org/wiki/Ted_Slevin?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Ted_Slevin"}},"extract":"Edward \"Ted\" Slevi